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目的 了解女性自然绝经以后，体内女性激素和白细胞介素２水平的改变对Ⅰ型骨质疏松症发病的影响，以及它们之间的相互关系。方法 选择９０例４１～７０岁间绝经前、后期健康的妇女，采用双能 Ｘ 线吸收测定法（ Ｄ Ｅ Ｘ Ａ）测定前、后位腰椎和左侧股骨近端骨密度（ Ｂ Ｍ Ｄ），用放射免疫分析方法（ Ｒ Ｉ Ａ）测定血清中 Ｅ２、 Ｐ、 Ｌ Ｈ 和 Ｆ Ｓ Ｈ 等女性激素水平，以及 Ｉ Ｌ２和 Ｂ Ｇ Ｐ含量。结果 １绝经后骨质疏松组血清中 Ｅ２和 Ｐ水平较绝经后非骨质疏松组略有下降，但是差别无意义。２比较绝经后骨质疏松组和非骨质疏松组中 Ｉ Ｌ２水平，差别无意义。相关分析表明 Ｉ Ｌ２和绝经年限、 Ｅ２、 Ｐ 以及 Ｆ Ｓ Ｈ 不相关，与 Ｌ Ｈ 呈显著的正相关（ｒ＝ ０２２９２ Ｐ＝ ００３１）。３绝经以后， Ｂ Ｇ Ｐ显著上升，并且与股骨颈 Ｂ Ｍ Ｄ 呈负相关（ｒ＝ － ０２３６７ Ｐ＝ ０００２６）。结论 １绝经后低水平的卵巢激素可能是不再继续影响骨量的主要因素。２ Ｉ Ｌ２有可能通过促进垂体前叶 Ｌ Ｈ 的释放，调节卵巢功能，间接影响女性骨量
Objective To understand the effect of changes of female hormones and interleukin-2 levels on the incidence of type I osteoporosis and their correlation after natural menopause. Methods Ninety healthy women aged 41-70 years before and after menopause were enrolled in this study. BMD of the anterior and posterior lumbar and proximal femur were measured by dual energy X-ray absorptiometry (D E X A) , And radioimmunoassay (RIA) was used to determine the levels of E2, P, LH and FSH in women and the contents of IL-2 and B G P in women. Results 1. The serum levels of E2 and P in postmenopausal osteoporosis group were slightly lower than those in non-postmenopausal non-osteoporosis group, but the differences were not significant. 2 Comparison of postmenopausal osteoporosis group and non-osteoporosis group I L 2 levels, the difference is meaningless. Correlation analysis showed that IL-2 was not related to menopause, E2, P and F S H, and had a significant positive correlation with L H (r = 0.2292 P = 0.031). 3 After menopause, B G P increased significantly, and negatively correlated with B M D of the femoral neck (r = -0.2367 P = 0.0026). Conclusion 1 low levels of postmenopausal ovarian hormones may be no longer continue to affect the main factors of bone mass. 2 I L 2 may be through the promotion of anterior pituitary LH release, regulating ovarian function, indirectly affecting the female bone mass