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目的探讨尿中2-萘酚作为焦炉工多环芳烃接触水平生物监测指标的可行性。方法以某市钢铁炼焦制气厂109名工人和50名本厂机关工作人员为对象,收集周末班后尿20 ml,用改良的碱解-高效液相色谱法测定尿中2-萘酚。焦炉作业环境多环芳烃的车间空气监测结果以苯并(a)芘的浓度水平表示。用单因素方差分析、2检验和Spearman等级相关分析。结果尿中2-萘酚浓度炉顶工、炉侧工、炉底工和对照组分别为(11.32±4.82)、(9.82±5.11)、(5.24±4.97)和(2.97±2.36)μmol/mol Cr,呈炉顶>炉侧>炉底>对照组的趋势;尿中2-萘酚浓度与多环芳烃接触水平呈正相关关系(r=0.435,P<0.001)。结论焦炉工尿中2-萘酚水平可有效地反映个体短期多环芳烃接触的内剂量水平,可作为焦炉工多环芳烃接触水平的生物监测指标。
Objective To investigate the feasibility of using 2-naphthol in urine as bio-monitoring indicator of PAHs contact level in coke oven workers. Methods A total of 109 workers in Coking Plant and 50 workers in the city’s coking plant were enrolled in this study. Twenty ml of urine was collected after weekends, and 2-naphthol in urine was determined by modified alkali hydrolysis-high performance liquid chromatography. Coke oven operating environment Polycyclic aromatic hydrocarbons workshop air monitoring results to benzo (a) pyrene concentration level. One-way analysis of variance, 2 test and Spearman rank correlation analysis. Results The urinary concentration of 2-naphthol was (11.32 ± 4.82), (9.82 ± 5.11), (5.24 ± 4.97) and (2.97 ± 2.36) μmol / mol Cr, and the trend of top> furnace side> hearth> control group. There was a positive correlation between the concentration of 2-naphthol in urine and PAH exposure (r = 0.435, P <0.001). Conclusion The level of 2-naphthol in urine of coke oven workers can effectively reflect the internal dosages of short-term PAH exposure and can be used as a bio-monitoring indicator of PAH exposure.