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应用胰岛素治疗糖尿病病人,除监测血糖值以外,目前已广泛使用糖基血红蛋白(GHb)的测定量来调节胰岛素剂量。测定GHb的方法较多,主要按电荷不同区别,并分出血红蛋白A。例如应用柱层析或琼脂凝胶电泳等技术。但使用这些方法时,因胎儿血红蛋白(HbF)随着GHb一起移动,因此如果有HbF,则出现GHb假性高值。例1 24岁女性,患糖尿病15年。每日注速效和中效胰岛素2次,按家用血糖试纸测定和微细血管血滤纸法核实血糖量,来调整胰岛素剂量。但检查结果一直显示正常或近乎正常。对比之下,用琼脂凝胶电泳测定GHb浓度却始终介乎13～16％之间(正常范围为5.5～7.5％),提示糖尿病控制欠
The use of insulin in patients with diabetes, in addition to monitoring blood glucose, has been widely used to measure the amount of glycohemoglobin (GHb) to regulate insulin dose. Determination of GHb more ways, mainly by the different charge, and the separation of hemoglobin A. For example, application of column chromatography or agarose gel electrophoresis techniques. However, when these methods are used, the hemoglobin (HbF) of the fetus moves with the GHb, so if there is HbF, a hypopigmentation value of GHb appears. A 24-year-old female with diabetes for 15 years. The daily injection of quick-acting and middle-acting insulin 2 times, according to the home blood glucose test strips and micro-vascular blood filter paper to verify the amount of blood sugar, to adjust the insulin dose. However, the test results have been shown to be normal or near normal. In contrast, the determination of GHb concentrations by agarose gel electrophoresis always ranged from 13 to 16% (normal range 5.5 to 7.5%), suggesting that diabetes control deficit