脑胶质瘤是发病率最高且最具有侵袭性的一种中枢神经系统恶性肿瘤。虽然显微神经外科技术、放射治疗及化疗水平不断提高,但对胶质瘤的治疗效果仍不尽如人意。因此,探索新的治疗方法势在必行。在众多的新型治疗方法中,肿瘤坏死因子相关凋亡诱导配体可通过与死亡受体结合诱导肿瘤细胞凋亡,而对正常组织无损伤,已受到越来越多的关注。 Glioma is the highest incidence and most aggressive type of central nervous system malignancies. Although the microneurosurgery technology, radiotherapy and chemotherapy levels continue to improve, but the treatment of glioma is still not satisfactory results. Therefore, exploring new treatments is imperative. Among the many novel therapeutic approaches, tumor necrosis factor-related apoptosis-inducing ligands have attracted more and more attention because they bind tumor death receptors and induce tumor cell apoptosis without any damage to normal tissues.