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目的:观察仙灵生白汤对化疗致白细胞减少者白细胞及KPS评分的影响。方法:将80例肿瘤患者按照随机数字表法分为对照组与观察组,各40例。根据患者病情不同分别采用GP或TP方案治疗;观察组于化疗基础上采用仙灵生白汤治疗;对照组于化疗基础上采用重组人粒细胞集落刺激因子皮下注射治疗。待化疗后观察2组白细胞计数、中性粒细胞、血红蛋白、血小板计数、生命质量(KPS)评分情况及不良反应。结果:治疗前2组患者白细胞计数、中性粒细胞、血红蛋白、血小板计数比较,差异均无统计学意义(P>0.05);2组患者白细胞计数、中性粒细胞、血红蛋白、血小板计数均较治疗前明显升高(P<0.05),观察组升高较对照组显著(P<0.05)。治疗前观察组KPS评分与对照组比较,差异无统计学意义(P>0.05);2组患者治疗后KPS评分均较治疗前明显升高(P<0.05),观察组上升较对照组更为显著(P<0.05)。结论:采用仙灵生白汤治疗可有效减少化疗所引起的白细胞损伤,改善患者生活质量,且无明显不良反应。
Objective: To observe the effect of Xianling Shengbai decoction on leukopenia and KPS score of chemotherapy-induced leukopenia. Methods: 80 cases of cancer patients were divided into control group and observation group according to random number table method, each 40 cases. Patients were treated with GP or TP regimen according to the patient’s condition. The observation group was treated with Xianling Shengbai Decoction on the basis of chemotherapy and the control group was treated by subcutaneous injection of rhG-CSF on the basis of chemotherapy. After chemotherapy, two groups of white blood cell count, neutrophil, hemoglobin, platelet count, quality of life (KPS) scores and adverse reactions were observed. Results: There was no significant difference in leucocyte count, neutrophil, hemoglobin and platelet count between the two groups before treatment (P> 0.05). The white blood cell count, neutrophil, hemoglobin and platelet count in the two groups were all significantly lower than those before treatment (P <0.05), the observation group was significantly higher than the control group (P <0.05). The KPS score of the observation group before treatment was not significantly different from that of the control group (P> 0.05). The KPS scores of the two groups were significantly higher than those before treatment (P <0.05) Significant (P <0.05). Conclusion: The treatment of xinglingsheng white soup can effectively reduce the leucocyte injury caused by chemotherapy and improve the quality of life of patients with no obvious adverse reactions.