前列腺癌是严重威胁欧美国家男性健康的恶性肿瘤。研究前列腺癌发生与发展的分子机制，尤其是从雄激素依赖性向雄激素非依赖性转化的分子机制对该病的诊断和治疗极为重要。前列腺癌转移LNCaP细胞模型包括LNCaP、C4、C4-2和C4-2B等一系列的遗传背景相同的细胞系，成功模拟前列腺癌细胞从雄激素依赖性发展到雄激素非依赖性，从不转移到转移各个阶段的基本生物行为学的特征，已成为当前应用最为广泛的前列腺癌细胞模型之一。 Prostate cancer is a serious threat to the health of men and women in Europe and the United States malignant tumors. To study the molecular mechanism of the occurrence and development of prostate cancer, especially the molecular mechanism from androgen-dependent to androgen-independent transformation is very important for the diagnosis and treatment of this disease. Prostate Cancer Metastasis LNCaP cell models include a series of cell lines of the same genetic background, such as LNCaP, C4, C4-2 and C4-2B, that successfully mimic the androgen-independent development of androgen-independent prostate cancer cells and never transfer It has become one of the most widely used prostate cancer cell models to transfer the characteristics of basic biological behavior in all stages.