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目的：本文探讨Ｌ－精氨酸对兔血脂和血流变的影响。方法：３０只雄兔随机分为以下３组：正常对照组（ＮＣ），高脂对照组（ＨＣ）和Ｌ－精氨酸组（ＬＡ），正常对照组为普通颗粒饲料组，后两组均为高胆固醇颗粒饲料组。实验开始前和实验第１０周，检测血清总胆固醇、甘油三酯和高密度脂蛋白以及血液流变各项指标。结果：实验１０周后，ＬＡ组和ＨＣ组的血清总胆固醇和甘油三酯都显著高于ＮＣ组（各为Ｐ＜０．００１），但前两组间比较无差异（Ｐ＞０．１）。治疗１０周后ＨＣ组各项血流变指标不仅明显高于实验前（各为Ｐ＜０．００１），而且显著高于ＬＡ组和ＮＣ组（Ｐ＜０．０１），但ＬＡ组和ＮＣ组血流变指标组间比较无差异（Ｐ＞０．０５）。结论：Ｌ－精氨酸不降低高脂兔血中胆固醇浓度，但明显改善其血液流变。
Objective: This article investigates the effect of L-arginine on serum lipids and blood rheology in rabbits. Methods: Thirty male rabbits were randomly divided into the following three groups: normal control group (NC), high fat control group (HC) and L-arginine group (LA), normal control group was ordinary pellet feed group, For high cholesterol pellet group. Before the start of the experiment and the tenth week of the experiment, the indexes of serum total cholesterol, triglyceride, high density lipoprotein and blood rheology were detected. Results: Serum total cholesterol and triglyceride levels of LA and HC groups were significantly higher than those of NC group (P <0.001) after 10 weeks of experiment, but there was no significant difference between the two groups (P> 0.1 ). After 10 weeks of treatment, all the indexes of hemorheology in HC group were significantly higher than those in LA group and NC group (P <0.01), but not in LA group and NC group No significant difference was found between the indexes of hemorheology (P> 0.05). CONCLUSION: L-arginine does not reduce the cholesterol concentration in hyperlipidemic rabbits, but significantly improves the blood rheology.