论文部分内容阅读
流行病学研究显示Ⅰ型糖尿病与肠道病毒感染相关。柯萨奇病毒B(CVB)可能是促使胰腺β细胞自身免疫损伤的原因。从糖尿病酮症酸中毒死亡患儿的胰腺中分离到CVB4E2株。CVB4E2株在某些小鼠中可引起β细胞自身免疫性糖尿病,但CVB4感染与免疫耐受缺失之间的关系尚不明确。胸腺上
Epidemiological studies have shown that type 1 diabetes is associated with enterovirus infection. Coxsackie virus B (CVB) may be the cause of pancreatic β-cell autoimmune damage. CVB4E2 strain was isolated from the pancreas of children with diabetic ketoacidosis. The CVB4E2 strain can cause beta-cell autoimmune diabetes in some mice, but the relationship between CVB4 infection and the loss of immune tolerance is unclear. Thymus