目的:研究右美沙芬咀嚼胶新型给药系统体外释放行为。方法:建立了新型右美沙芬咀嚼胶给药系统中药物释放的测定法;运用溶出仪法、冲压法和夹剪法进行体外释放实验,采用拟合因子法比较各评价方法。结果:3种方法测得的释放行为差异无显著性,优选溶出仪法进行测定。结论:溶出仪法、冲压法和夹剪法均可用于测定咀嚼胶新型给药系统的体外释放,优选溶出仪法。 Objective: To study the in vitro release behavior of dextromethorphan chewing gum. Methods: A new dextromethorphan chewing gum drug delivery system was established for the determination of drug release. The dissolution test, stamping method and in vitro release test were used to compare the evaluation methods. Results: There was no significant difference in the release behavior measured by the three methods, and the dissolution method was the best. Conclusion: The dissolution method, stamping method and clip-on method can all be used to determine the in vitro release of chewing gum new drug delivery system.