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利用系列含烯二炔结构的2(5H)-呋喃酮衍生物与叠氮化钠发生串联的成环反应,在优化的反应条件下,即反应溶剂为DMF、反应时间48 h、反应温度30℃时、NaN3为1.5 equiv.,以中等产率(42%～62%)合成了系列新型的稠合三环2(5H)-呋喃酮衍生物,其可以进一步高产率地(94%～96%)衍生为吡啶稠合的2(5H)-呋喃酮化合物.所有新化合物的结构用IR,1H NMR,13C NMR,MS,元素分析等方法进行了表征.该串联反应合成途径简捷、反应条件温和,无需添加催化剂,可为具有含三唑结构的稠杂环化合物合成提供简便的途径.
A series of ring-forming reactions of 2 (5H) -furanone derivatives containing sodium enediyne with sodium azide were carried out under the optimized reaction conditions, ie, the reaction solvent was DMF, the reaction time was 48 h, the reaction temperature was 30 (NaN3) was 1.5 equiv. A series of novel fused tricyclic 2 (5H) -furanone derivatives were synthesized in moderate yield (42% ~ 62% %) Is a pyridine-fused 2 (5H) -furanone compound.The structures of all the new compounds were characterized by IR, 1H NMR, 13C NMR, MS, elemental analysis, etc. The synthesis route of the tandem reaction was simple and the reaction conditions Mild, without adding a catalyst, for the synthesis of heterocyclic heterocyclic compounds containing triazole structure provides a simple way.