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目的:研究胃仙治效剂对胃溃疡的作用。方法:接改良的OKabe法和使用乙醇制造大鼠实验性胃溃疡模型。实验大鼠分为四组,即对照组(蒸馏水)、法英替丁用(3.6mg/kg/日)、胃仙治高剂量组(浓度100%)、骨仙治低剂量组(浓度50%)。乙醇所致的溃疡组,模型制备后三天开始给药,乙醇所致溃病组模型制备前给药。均每日二次灌胃,连续15天,每次给药2.0ml/200g容积。最后一次给药的次日剖检大鼠,计算溃疡指数及观察有无穿孔。结果:给药组作用与对照组相比,均有显著性差异,胃仙治高剂量组作用优于法莫替丁组。结论:胃仙治煎剂具有抗大鼠实验性溃疡作用。
Objective: To study the effect of Weixian efficacy agent on gastric ulcer. METHODS: The modified OKabe method and the ethanol-produced rat experimental gastric ulcer model were used. The rats were divided into four groups: the control group (distilled water), famotidine (3.6 mg/kg/day), the high-dose group (100% concentration), and the low-dose group (concentration). 50%). In the ulcer group caused by ethanol, three days after the preparation of the model, the model was administered, and the ethanol-induced ulceration group model was administered before preparation. Both were fed twice daily for 15 consecutive days and 2.0 ml/200 g volume was administered each time. The day after the last administration, the rats were necropsied and the ulcer index was calculated and observed for perforation. Results: Compared with the control group, there was a significant difference in the effect of the drug administration group. The high dose of Weixianzhi group was better than the famotidine group. Conclusion: Wei Xian Xian decoction has anti-rat ulcer effect.