To highlight the development and achievements of hemostasis and thrombosis research in China over the past 50 years Data sources Both Chinese and English language literature search using MEDLINE (1990 1998), and original articles published in the main Chinese and international journals Study selection After reviewing all the main articles on thrombosis and hemostasis, 20 of them were selected that specifically addressed the stated purpose.Date extracion The content that could present the progress in hemostasis and thrombosis in China was selected.Results Monoclonal antibodies have widely been used in basic research and laboratory diagnosis. Several novel gene mutations of coagulation factors have been identified. Some drugs of traditional Chinese medicine have proved to be efficient in treatment of thrombotic diseases.Conclusions Significant achievements in basic, clinical and pharmacological research in the field of hemostasis and thrombosis have been made in China in the past 50 years. Some new discoveries in platelet membrane glycoproteins and coagulation factors research are believed to be contributions to the international scientific community. However, a specific effort using advanced techniques should be made for future development, especially in molecular biology research. To highlight the development and achievements of hemostasis and thrombosis research in China over the past 50 years Data sources Both Chinese and English language literature search using MEDLINE (1990 1998), and original articles published in the main Chinese and international journals Study selection After reviewing all the main articles on thrombosis and hemostasis, 20 of them were selected that specifically address the stated purpose. Date extracion The content that could present the progress in hemostasis and thrombosis in China was selected. Results Monoclonal antibodies have been used in basic research and laboratory diagnosis. Several novel gene mutations of coagulation factors have been identified. Some drugs of traditional Chinese medicine have proved to be efficient in treatment of thrombotic diseases. Conclusions Significant achievements in basic, clinical and pharmacological research in the field of hemostasis and thrombosis have been made in China in the past Some new discoveries in platelet membrane glycoproteins and coagulation factors research are believed to be contributions to the international scientific community. However, a specific effort using advanced techniques should be made for future development, especially in molecular biology research.