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目的 观察乌司他丁对休克患者肾功能的保护作用。方法 入选 2 8例休克患者随机分为乌司他丁治疗组和对照组 ,治疗组在常规抗休克治疗的同时给乌司他丁 2 0万U ,加入生理盐水 10 0ml,q8h静滴 ;对照组常规抗休克治疗 ,方案与观察组相同。观察两组的尿量、肾功能恢复情况。结果 与对照组比较 ,治疗组尿量明显增加 ,尿NAG(N 乙酰 β 氨基葡萄糖苷酶 )、α1 微球蛋白明显减少 ,血BUN和Scr明显低于对照组。治疗组患者在观察期间需要行持续肾脏替代治疗的百分率为 14 2 8% ,明显低于对照组的 5 7 14 %。结论 乌司他丁具有保护肾小管功能及促进休克患者肾功能恢复的作用。
Objective To observe the protective effect of ulinastatin on renal function in patients with shock. Methods Twenty-eight shock patients were randomly divided into ulinastatin group and control group. The treatment group received 200,000 U of ulinastatin simultaneously with conventional anti-shock therapy, and the rats were treated with normal saline (10ml, q8h) Group conventional anti-shock treatment, the same protocol and observation group. Urine volume and renal function recovery of the two groups were observed. Results Compared with the control group, the urine volume of the treatment group was significantly increased, urinary NAG (N acetyl β-glucosaminidase) and α1 microglobulin were significantly decreased, and the levels of BUN and Scr in blood were significantly lower than those in the control group. The percentage of patients who underwent continuous renal replacement therapy during the observation period in the treatment group was 14.28%, significantly lower than the control group of 57.4%. Conclusion Ulinastatin can protect the renal tubular function and promote the recovery of renal function in patients with shock.