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目的研究肝细胞生长因子(HGF)在肺腺癌与细支气管肺泡细胞癌的表达。方法应用免疫组化方法检测44例Ⅰ期肺腺癌与32例细支气管肺泡细胞癌手术切除标本HGF的表达,并统计5年生存率。结果肺腺癌与细支气管肺泡细胞癌细胞HGF阳性表达率分别为66.3%与85.4%(P=0.012);肺腺癌与细支气管肺泡细胞癌细胞HGF染色积分为4.08±0.72与5.41±0.89,差异有统计学意义(P=0.009)。Ⅰ期肺腺癌与细支气管肺泡细胞癌的5年生存率为68.2%与81.3%,差异有统计学意义(P=0.045)。结论HGF在肺腺癌与细支气管肺泡细胞癌的表达存在差异。
Objective To study the expression of hepatocyte growth factor (HGF) in lung adenocarcinoma and bronchioloalveolar cell carcinoma. Methods Immunohistochemistry was used to detect the expression of HGF in 44 cases of stage I lung adenocarcinoma and 32 cases of bronchioloalveolar cell carcinoma. The 5-year survival rate was calculated. Results The positive rates of HGF expression in lung adenocarcinoma and bronchioalveolar cell carcinoma were 66.3% and 85.4% (P = 0.012), respectively. The scores of HGF staining in lung adenocarcinoma and bronchioalveolar cell carcinoma were 4.08 ± 0.72 and 5.41 ± 0.89, The difference was statistically significant (P = 0.009). The 5-year survival rates of stage I lung cancer and bronchioloalveolar carcinoma were 68.2% and 81.3%, respectively, with significant differences (P = 0.045). Conclusion The expression of HGF in lung adenocarcinoma and bronchioloalveolar cell carcinoma is different.