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目的:通过总结分析国内有关轻微肝性脑病(minimal hepatic encephalopathy,MHE)的文献,阐明目前国内MHE的研究现状。方法:选取36篇近10年来国内公开发表的有关MHE发病机理、诊断、防治的文献进行综合阅读及评述。结果:文献报道显示,国内众多学者对MHE的研究取得了一定的进展,但也存在一些问题。结论:MHE的定义尚未完全统一,诊断的金标准尚未完全获得统一认识,无法确定统一的诊断标准;临床研究缺乏大样本的随机对照研究,数据缺乏说服力,可重复性差。这些问题需要我们在今后的研究中加以关注和解决。
OBJECTIVE: To summarize and analyze the domestic literature about minimal hepatic encephalopathy (MHE) and clarify the current research status of MHE in China. Methods: Thirty-six literatures about the pathogenesis, diagnosis and prevention and treatment of MHE published in the past 10 years in our country were comprehensively read and reviewed. Results: The literature shows that many domestic scholars have made some progress in the study of MHE, but there are also some problems. Conclusions: The definition of MHE has not been completely unified. The gold standard of diagnosis has not been fully recognized and can not be used to determine the uniform diagnostic criteria. The clinical study lacks a large randomized controlled study. The data are not convincing and the reproducibility is poor. These issues need our attention in the future research and solve.