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目的:观察心肺转流(CBP)对狗心脏停搏30分钟后的心肺复苏效果。方法:用静脉注射10％氯化钾溶液使狗心搏、呼吸骤停30分钟后,分两组进行心肺复苏,每组6只。对照组用常规法,实验组用CPB法,进行心电图、动脉压、静脉压、动脉血气监测和观察瞳孔,30分钟后观察复苏效果。结果:对照组仅1例于第15分钟后恢复自主循环,瞳孔开始缩小,其余均未能复苏(20％)。实验组于2—3分钟后全部恢复自主循环(100％),瞳孔缩小。复苏30分钟后,实验组平动脉压、PaO2明显高于对照组(P<0.05)。实验组静脉压和PaCO2明显低于对照组。大脑皮层及海马区脑组织Ca-Mg-ATP酶活性实验组也高于对照组。结论:心脏呼吸骤停30分钟后,用心肺转流法复苏能有地恢复自主循环,并可能有益于脑复苏,其复苏效果明显优于常规法。
Objective: To observe the effects of cardiopulmonary bypass (CBP) on cardiopulmonary resuscitation after 30 minutes of cardiac arrest in dogs. Methods: 10% potassium chloride solution intravenous injection of heart beats, respiratory arrest 30 minutes, divided into two groups CPR, 6 in each group. In the control group, the conventional method was used. In the experimental group, CPB method was used to monitor the pupil by electrocardiogram, arterial pressure, venous pressure and arterial blood gas, and the recovery effect was observed after 30 minutes. Results: In the control group, only 1 patient recovered autonomic circulation after the 15th minute, the pupils began to shrink, and the rest failed to recover (20%). Experimental group in 2-3 minutes after the full recovery of spontaneous circulation (100%), miosis. After recovery for 30 minutes, the mean arterial pressure and PaO2 in the experimental group were significantly higher than those in the control group (P <0.05). The experimental group venous pressure and PaCO2 was significantly lower than the control group. Cerebral cortex and hippocampus brain tissue Ca-Mg-ATPase activity of the experimental group is also higher than the control group. CONCLUSIONS: Cardiopulmonary resuscitation can restore spontaneous circulation after cardiorespiratory arrest for 30 minutes and may be beneficial to cerebral resuscitation. The recovery is obviously superior to the conventional method.