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1962年Lennox等发现21-三体胎儿中性粒细胞碱性磷酸酶(NAP)增高,同样也见于13-三体及18-三体胎儿,其来源不明,因而重要的是检查21-三体胎儿双亲的NAP活性。现今,碱性磷酸酶(AP)同工酶常用作细胞生物学遗传标记,并在医学中作组织与器官疾病的参数。作者对25例21-三体胎儿的孕妇做了NAP分析,这些胎儿的染色体畸变,业经羊水穿刺,并由细胞遗传学检查所确定。孕20～22周时抽血,用细胞化学及生物化学方法,作酶检查,同时选择29例相同孕期的正常孕妇做对照。全部检查对象均做外周淋巴细胞培养,进行染色体组型分析。每组取10
1962 Lennox et al found that 21-trisomy fetal neutrophil alkaline phosphatase (NAP) increased, also found in 13-trisomy 18 and trisomy 18, whose source is unknown, it is important to check the 21-trisomy Fetal parental NAP activity. Alkaline phosphatase (AP) isozymes are commonly used today as genetic markers of cell biology and are used in medicine as parameters of tissue and organ diseases. The authors performed a NAP analysis of 25 pregnant women with 21-trisomy. Chromosomal aberrations in these fetuses were determined by amniocentesis and cytogenetics. 20 to 22 weeks pregnant when drawing blood, using cytochemical and biochemical methods for enzyme examination, while selecting the same 29 cases of normal pregnant women during pregnancy as a control. All subjects were peripheral lymphocyte culture, chromosome analysis. Take 10 for each group