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目的探讨盐酸氨溴索联合头孢他啶对新生儿感染性肺炎患儿血清C-反应蛋白(CRP)、降钙素原(PCT)、白细胞计数(WBC)水平变化的影响。方法选取62例新生儿感染性肺炎患儿,随机数字表法分为对照组与研究组,每组31例。对照组仅采用头孢他啶,研究组联合采用头孢他啶及盐酸氨溴索,两组均持续治疗7 d。疗程结束后比较两组临床疗效、临床症状消失时间、入院时及疗程结束后血清CRP、PCT、WBC水平。结果研究组治疗有效率93.55%(29/31)高于对照组67.74%(21/31),差异有统计学意义(P<0.05);治疗前研究组血清CRP、PCT、WBC水平与对照组比较差异未见统计学意义(P>0.05),治疗后两组血清CRP、PCT、WBC水平较治疗前降低,且研究组低于对照组,差异有统计学意义(P<0.05);研究组肺部啰音消失时间、体温恢复正常时间、咳嗽消失时间、住院时间少于对照组,差异有统计学意义(P<0.05)。结论联合采用头孢他啶及盐酸氨溴索治疗新生儿感染性肺炎效果显著,可有效降低患儿血清CRP、PCT、WBC水平,缩短临床症状改善用时,提高治疗效果。
Objective To investigate the effects of ambroxol combined with ceftazidime on the changes of serum C-reactive protein (CRP), procalcitonin (PCT) and white blood cell count (WBC) in neonates with infectious pneumonia. Methods Sixty-two neonates with infectious pneumonia were selected and randomly divided into control group and study group, with 31 cases in each group. In the control group, only ceftazidime was used. In the study group, ceftazidime and ambroxol hydrochloride were used in combination. Both groups were treated for 7 days. After treatment, the clinical efficacy, the disappearance of clinical symptoms, the levels of serum CRP, PCT and WBC after admission and after the end of treatment were compared. Results The effective rate of treatment in study group was 93.55% (29/31), which was significantly higher than 67.74% (21/31) in control group (P <0.05). The levels of CRP, PCT and WBC in study group before treatment were significantly lower than those in control group The difference was not statistically significant (P> 0.05). After treatment, the levels of serum CRP, PCT and WBC in both groups were lower than those before treatment, and the difference was statistically significant (P <0.05) Pulmonary rales disappeared time, body temperature returned to normal time, cough disappear time, hospital stay less than the control group, the difference was statistically significant (P <0.05). Conclusions The combination of ceftazidime and ambroxol hydrochloride has significant effect on neonatal pneumonia, which can effectively reduce the level of serum CRP, PCT and WBC in children and shorten the time of improvement of clinical symptoms, and improve the therapeutic effect.