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目的探讨三联与四联用药治疗消化性溃疡的临床疗效,并对比其疗效差异。方法将82例在我院接受治疗的消化性溃疡患者随机分为三联组和四联组各41例,三联组患者采用奥美拉唑、甲硝唑及阿莫西林进行联合治疗,四联组患者在三联组的用药基础上,加用胃得安进行联合治疗,治疗结束后观察两组患者临床疗效并进行对比。结果两组患者经过治疗后,四联组Hp转阴率为93.8%,总有效率为94.9%,与三联组Hp转阴率为84.1%及总有效率为85.8%相比较,差异均有统计学意义(P<0.05)。结论四联用药法相对三联用药法对于消化性溃疡具有更显著的临床疗效,值得在临床进行推广。
Objective To investigate the clinical efficacy of triple and quadruple drugs in the treatment of peptic ulcer, and to compare the difference in therapeutic effect. Methods Eighty-two patients with peptic ulcer treated in our hospital were randomly divided into triple therapy group and quadriceps therapy group, 41 patients in triple therapy group were treated with omeprazole, metronidazole and amoxicillin, Patients in the triple group based on the medication, plus the use of stomach for the joint treatment, after the end of treatment observed the clinical efficacy of two groups of patients and compared. Results After treatment, the Hp negative conversion rate was 93.8% in the quadruple group and the total effective rate was 94.9%. Compared with the triple combination group, the Hp negative conversion rate was 84.1% and the total effective rate was 85.8% Significance (P <0.05). Conclusion Compared with the triple quadruple drug therapy for peptic ulcer with more significant clinical efficacy, it is worth in the clinical promotion.