目的 评价早期应用百忧解对卒中后抑郁的康复疗效。方法 46例脑卒中病人 (A组 )给予百忧解 20 mg 1次 /d。另设对照组 (B组 )50例仅给脑卒中药物治疗。 4周后进行肌力、抑郁自评量表 (SDS)、 ADL能力比较进行自身对照及组间对照。结果 A组的肌力、 ADL能力均好于 B组。 A组抑郁病人从疗前 20例 (40.48％ )减少到 9例 (20％ )， B组却从疗前 20例 (40％ )增加至 24例 (48％ )。结论 早期百忧解能治疗急性脑梗死的抑郁症和预防抑郁情绪，增加病人康复的主观能动性，有利于改善肌力和 ADL能力。 Objective To evaluate the effect of early application of Prozac on the rehabilitation of post-stroke depression. Methods 46 stroke patients (group A) were given Prozac 20 mg once daily. Another set of control group (B group) 50 cases only for stroke drug treatment. After 4 weeks, Self-rating Muscles, Depression Scale (SDS) and ADL were compared with self-control and between-group control. Results A group of muscle strength, ADL ability were better than the B group. In group A, the number of depressed patients decreased from 20 (40.48%) to 9 (20%) before treatment, while that in group B increased from 20 (40%) to 24 (48%) before treatment. Conclusions Prozac can treat depression and prevent depression in patients with acute cerebral infarction and increase the subjective initiative of patients’ recovery, which is beneficial to improve muscle strength and ADL ability.