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【目的】探求特发性中枢性性早熟儿童血浆骨骼生长标志物NTproCNP水平变化,以及其与IGF-I和雌二醇之间的关系。【方法】16名特发性中枢性性早熟女童及16例年龄相当的正常女童为研究对象,测量身高、体重,计算骨龄。骨龄评价采用TW2法。ELISA测定血清IGF-I和C型钠尿肽前体氨基末端肽(NTproCNP);化学发光法测定雌二醇。【结果】特发性中枢性性早熟女童与正常对照组女童血浆NTproCNP水平分别为(18.92±8.62)pmol/mL和21.74(13.12)pmol/mL(Z=2.34,P<0.05);血清IGF-I水平分别为(867.50±318.15)ng/mL和(522.41±228.33)ng/mL(t=3.59,P<0.05);血清雌二醇水平分别为(37.19±16.08)pg/mL和19.00(4.5)pg/mL,差异均有统计学意义(Z=2.58,P<0.05)。血浆NTproCNP水平与血清IGF-I无相关性,二者与雌二醇也无相关性。【结论】特发性中枢性性早熟女童血循环骨骼生长标志物NTproCNP升高。
【Objective】 To investigate the changes of NTproCNP, a marker of plasma bone growth in children with idiopathic central precocious puberty, and its relationship with IGF-I and estradiol. 【Methods】 Sixteen girls with idiopathic central precocious puberty and 16 normal girls of the same age were enrolled in this study. Height and weight were measured, and bone age was calculated. Bone age evaluation using TW2 method. Serum IGF-I and C-terminal natriuretic peptide (NTproCNP) were determined by ELISA. Estradiol was detected by chemiluminescence method. 【Results】 The levels of plasma NTproCNP in girls with idiopathic central precocious puberty and normal controls were (18.92 ± 8.62) pmol / mL and 21.74 (13.12) pmol / mL respectively (Z = 2.34, P < I levels were (867.50 ± 318.15) ng / mL and (522.41 ± 228.33) ng / mL respectively (t = 3.59, P 0.05) .The levels of serum estradiol were (37.19 ± 16.08) pg / mL and 19.00 ) pg / mL, the differences were statistically significant (Z = 2.58, P <0.05). Plasma NTproCNP levels had no correlation with serum IGF-I, nor did they correlate with estradiol. 【Conclusion】 NTproCNP, a marker of blood circulation skeletal growth in girls with idiopathic central precocious puberty, is elevated.