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费休氏水分测定法是利用碘在吡啶和甲醇溶液中氧化二氧化硫时需要定量的水参与反应的原理来测定样品中的水分含量,《中国药典(2010年版二部)》规定,盐酸克林霉素的水分测定采用费休氏法。本文通过对该法检查盐酸克林霉素胶囊的水分不确定度进行分析,全面考查主要影响因素,从而反映其水分测定的置信度和准确性,客观地评价测量结果的真实程度。
Fisher’s determination of water is the use of iodine in pyridine and methanol oxidation of sulfur dioxide, the need for quantitative water involved in the reaction principle to determine the moisture content of the sample, “Chinese Pharmacopoeia (2010 edition 2”) ", Clin. The determination of water using the Fisher method. In this paper, we analyzed the moisture uncertainty of clindamycin hydrochloride capsules and investigated the main influencing factors in an all-round way to reflect the confidence and accuracy of moisture determination and objectively evaluate the trueness of the measurement results.