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目的:分析不同症状分腹泻型肠易激综合征患者食物特异性抗体IgG(sIgG)及IgE(sIgE)表达。方法:连续选择近期就诊的腹泻型IBS患者43例,并按IBS总体症状分组(高症状分腹泻型IBS组,23例和低症状分腹泻型IBS组,20例),对照组为35例同龄、同性别的同期健康体检者。入选对象均接受了外周血sIgG及sIgE检测。结果:腹泻型IBS组外周血sIgG及sIgE表达阳性例数和阳性率均明显多于对照组,同时高症状分腹泻型IBS组外周血sIgG表达阳性例数和阳性率均明显多于低症状分腹泻型IBS组(P<0.05～0.01)。结论:腹泻型IBS患者外周血存在明确sIgG及sIgE优势表达,这种表达与腹泻型IBS症状轻重有密切关系。
OBJECTIVE: To analyze food-specific IgG (sIgG) and IgE (sIgE) expression in patients with diarrhea-predominant irritable bowel syndrome with different symptoms. Methods: Forty-three patients with diarrhea-type IBS were enrolled in this study. They were grouped according to the general symptoms of IBS (IBS with high symptom diarrhea, 23 with IBS and 20 with low-symptom diarrhea) and 35 , The same period of the same period health examination. Subjects were accepted peripheral blood sIgG and sIgE detection. Results: The positive rate of sIgG and sIgE expression in peripheral blood of diarrhea-predominant IBS patients were significantly higher than that of the control group. Meanwhile, the positive rate of sIgG expression in peripheral blood of IBS patients with diarrhea was significantly higher than that of low symptom scores Diarrhea type IBS group (P <0.05 ~ 0.01). Conclusion: There is a clear expression of sIgG and sIgE in peripheral blood of patients with diarrhea-type IBS. This expression is closely related to the severity of diarrhea-type IBS.