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目的探讨高血压病患者颈动脉内膜-中膜厚度与C反应蛋白的相关性。方法选择95例高血压病患者(高血压组)及60例健康体检者(对照组),采用感酶联免疫吸附试验测定血清C反应蛋白浓度,应用B超检测颈动脉内膜中层厚度,并对测定结果进行统计学分析。结果高血压病组C反应蛋白浓度、颈动脉内中膜厚度显著高于正常对照组,差异有统计学意义(P<0.01)。结论高血压病患者血清C反应蛋白浓度与颈动脉内中膜厚度关系密切,可能参与了高血压病动脉粥样硬化的发生、发展。
Objective To investigate the correlation between carotid intima-media thickness and C-reactive protein in patients with essential hypertension. Methods Ninety-five patients with hypertension (hypertension group) and 60 healthy subjects (control group) were enrolled in this study. Serum C-reactive protein was detected by enzyme-linked immunosorbent assay (ELISA), and carotid intima-media thickness The results of the statistical analysis. Results The levels of C-reactive protein and carotid intima-media thickness in hypertension group were significantly higher than those in control group (P <0.01). Conclusion Serum C-reactive protein in patients with hypertension is closely related to the carotid intima-media thickness, which may be involved in the occurrence and development of atherosclerosis in hypertensive patients.