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磁小体是一类存在于趋磁细菌体内,表面由脂质双分子层包裹,对磁场具有敏感性的纳米级单磁畴晶体.凭借其良好的生物相容性及表面可修饰等显著优势,可作为一种新型的天然磁性纳米载体应用于多种生物活性物质的固定负载,在靶向治疗方面有着广阔的应用前景.本文主要介绍了天然磁小体的来源及较人造磁性纳米颗粒的结构优势,概括了磁小体用作药物靶向载体的最新研究进展,并在此基础上探讨了磁小体载药研究中存在的问题及其发展前景.
Magnetosomes are a class of nanoscale single-domain crystals that exist in magnetotactic bacteria and are surrounded by lipid bilayers and sensitive to magnetic fields. Due to their good biocompatibility and surface modifiability , Can be used as a new type of natural magnetic nanocarrier for a fixed load of a variety of bioactive substances and has broad application prospects in the field of targeted therapy.This paper mainly introduces the origin of natural magnetosomes and comparison of the origin of artificial magnetic nanoparticles Structure advantage, summarizes the latest research progress of magnetosome as a drug targeting vector, and on this basis, discusses the problems in the study of magnetosome drug delivery and its development prospects.