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自1963年Brunberg发现澳抗(Au)以来,乙型病毒性肝炎(以下简称乙肝)与肝癌关系受到国内外许多学者的关注,他们研究发现:肝癌病人多有肝炎病史,HBV感染率相当高,肝癌病人肝组织中HBsAg和抗—HBc阳性与对照组差异非常显著,尤其近十年来肝癌细胞株的培养又能定量产生HBsAg,这些都表明乙肝与肝癌有非常密切的关系。为了排除肝癌与其他因素的关系,我们采用病例对照研究方法,对乙肝与肝癌关系作些验证工作,现将结果报导如下:
Since Brunberg discovered Au anti-Au in 1963, the relationship between hepatitis B and hepatocellular carcinoma has drawn much attention from many scholars both at home and abroad. They found that many patients with hepatocellular carcinoma have a history of hepatitis, HBV infection rate is very high, and liver cancer In patients with liver tissue HBsAg and anti-HBc positive and the control group difference is very significant, especially in the past 10 years, the cultivation of liver cancer cell lines can produce HBsAg quantitative, which shows that hepatitis B and liver cancer have a very close relationship. In order to rule out the relationship between liver cancer and other factors, we use case-control study to verify the relationship between hepatitis B and liver cancer. The results are reported as follows: