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目的:明确左炔诺孕酮紧急避孕(LNG-EC)暴露是否对妊娠晚期胎盘产生相关影响。方法:选择21例末次月经后使用过LNG-EC药孕妇计划剖宫产的产后胎盘为研究组,21例正常妊娠孕产妇计划剖宫产的产后胎盘为对照组。采用电子显微镜观察胎盘绒毛和细胞器超微结构;采用免疫组织化学方法检测孕妇胎盘中雌激素受体(ER)、孕激素受体(PR)、雄激素受体(AR)和增殖核抗原Ki67、凋亡相关分子caspase-3/8/9的表达情况。结果:光学显微镜和电子显微镜下胎盘形态学组间无统计学差异(P>0.05);胎盘中ER、PR、AR、Ki67和caspase-3/8/9的表达组间无显著统计学差异(P>0.05)。结论:左炔诺孕酮用于紧急避孕不影响其失败后妊娠晚期胎盘的形态结构、性激素受体表达和胎盘增殖及老化。
Aims: To determine if levonorgestrel emergency contraception (LNG-EC) exposure has a relevant effect on placenta in late pregnancy. Methods: Twenty-one cases of postpartum placenta who had used cesarean section after the last menstrual period were enrolled in the study group and 21 cases of normal pregnant women planned cesarean section as the control group. The ultrastructure of placenta villi and organelles were observed by electron microscope. The levels of estrogen receptor (ER), progesterone receptor (PR), androgen receptor (AR) and proliferating nuclear antigen Ki67 in placenta of pregnant women were detected by immunohistochemistry. Apoptosis related molecules caspase-3/8/9 expression. Results There was no significant difference between the placenta morphology under light microscope and electron microscope (P> 0.05). There was no significant difference in the expressions of ER, PR, AR, Ki67 and caspase-3/8/9 P> 0.05). CONCLUSIONS: Levonorgestrel, used in emergency contraception, does not affect the morphology, sex hormone receptor expression and placental proliferation and aging of placenta in late pregnancy after its failure.