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本文测定了45例中、晚期孕妇和其胎儿血清B_(12)浓度以及胎儿肝、脾、肾、脑、心肌五种组织的B_(12)浓度和储量。妊晚期孕妇血清B_(12)浓度比妊中期明显降低,这是血液稀释、胎儿生长、激素作用和B_(12)结合蛋白的改变共同作用的结果。胎儿血清B_(12)浓度显著高于同期孕妇,说明孕母供给胎儿B_(12)是一个主动过程。胎儿肝脏B_(12)浓度和储量最高。大于28周组的胎儿各脏器B_(12)储量显著高于小于28周组,说明胎儿体内B_(12)的储存主要是在妊娠后期。
In this paper, we measured the concentrations of B 12 and the concentrations of B 12 in fetal and fetal liver, spleen, kidney, brain and myocardium in 45 middle and late pregnant women and their fetuses. Serum B_ (12) concentrations in pregnant women at the second trimester were significantly lower than those at the second trimester. This was the result of a combination of hemodilution, fetal growth, hormonal effects and changes in the B 12 binding protein. Fetal serum B_ (12) concentration was significantly higher than the same period pregnant women, indicating that fetus feeding fetus B_ (12) is an active process. Fetal liver B_ (12) concentration and the highest reserves. B 12 storage in fetus of more than 28 weeks group was significantly higher than those of less than 28 weeks group, indicating that fetal B 12 storage was mainly in late pregnancy.