本文论述了对将要出国的78名瑞典旅游者从1977年11月到1978年9月分两组进行了预防接种,其中一组33人用0.5ml 热处理灭活伤寒菌苗进行皮下接种,另一组45人用该菌苗0.1ml(相当于皮下接种量1/5)进行皮内接种。大部分旅游者在第一次接种2—4周后进行了第二次接种,因为在第二次接种后短期内大多数人已出国,因此仅有13人可继续进行进一步抗体分析。所用菌苗由瑞典斯德哥尔摩国立细菌学实验室制备的热处理灭活伤寒菌苗,以0.5%酚为防腐剂,1 ml 内含灭活菌苗大约10亿个。接种部位在上臂。为检查免疫效果,测定了血浆沙门氏伤寒 O 抗体,在接种前采一次血,在两周内未出国者于首次接种后2—4周采第二次血。对 This article discusses the vaccination of 78 Swedish tourists going abroad from November 1977 to September 1978 in two groups, of which 33 were subcutaneously inoculated with 0.5 ml of heat-killed inactivated typhoid vaccine and the other Group of 45 people with the vaccine 0.1ml (equivalent to subcutaneous inoculum 1/5) for intradermal inoculation. Most travelers underwent a second vaccination 2-4 weeks after the first vaccination, as most of the people had traveled abroad shortly after the second vaccination, so only 13 of them could proceed with further antibody analyzes. The bacterin used was inactivated by a heat treatment prepared by the National Bacteriological Laboratory in Stockholm, Sweden, containing about 1 billion inactivated vaccine cells in 1 ml with 0.5% phenol as preservative. Vaccination site in the upper arm. To check for immune effects, plasma Salmonella typhimurium O antibody was measured and blood was collected prior to vaccination, with the second blood taken 2-4 weeks after the first vaccination in two weeks. Correct