论文部分内容阅读
目的 探讨一氧化氮 (NO)、γ -干扰素 (IFN -γ)在糖尿病视网膜病变中的意义 方法 检测糖尿病无视网膜病变患者 (NDR)、糖尿病视网膜病变患者 (DR)及正常人血中NO、IFN -γ的含量 ,进行对比分析。结果 NDR组NO显著高于正常对照组 (P <0 0 1) ,IFN -γ与对照组相比无显著差异 (P >0 0 5 ) ;DR组NO含量与正常对照组差异不显著 (P >0 0 5 ) ,而明显低于糖尿病无眼底病组 (P <0 0 5 ) ;DR组IFN -γ明显低于正常对照组 (P <0 0 5 ) ,且明显低于糖尿病无眼底病组 (P <0 0 1)。结论 NO、IFN -γ共同参与了糖尿病视网膜病变的发病机制 ;NO、IFN -γ的检测 ,有助于糖尿病视网膜病变的诊断 ;对NO、IFN -γ的深入研究 ,有望为糖尿病视网膜病变的治疗开辟新的途径。
Objective To investigate the significance of nitric oxide (NO) and interferon - γ (IFN - γ) in diabetic retinopathy. Methods The levels of NO and NO in diabetic patients without retinopathy (DR), diabetic retinopathy (DR) IFN-γ content, comparative analysis. Results NO in NDR group was significantly higher than that in normal control group (P <0.01), while there was no significant difference between IFN-γ and control group (P> 0.05). NO content in DR group was not significantly different from that in control group (P <0.05), while the level of IFN-γ in DR group was significantly lower than that in the normal control group (P <0.05), and was significantly lower than that of diabetic eyes without fundus disease Group (P <0 0 1). Conclusions NO and IFN-γ are involved in the pathogenesis of diabetic retinopathy. The detection of NO and IFN-γ is helpful for the diagnosis of diabetic retinopathy. The further study of NO and IFN-γ may be useful for the treatment of diabetic retinopathy Open up new avenues