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肌红蛋白是骨胳肌的正常组成部份。当肌肉受到创伤时,肌红蛋白即可出现在血清或尿中。由于分子很小(分子量17,000),又不和其他血清蛋白结合,肌红蛋白很快从肾脏滤过,由小便排出。因此,尿中肌红蛋白可以很早就出现,并随肌肉坏死范围的大小而持续一定时间。心肌肌红蛋白和骨胳肌肌红蛋白在免疫学上是一致的。许多作者曾在心肌受损,特别是心肌梗塞患者,用免疫测定方法在尿和血清中测得肌红蛋白。本文观察肌红蛋白尿与急性心肌梗塞的关系,并指出放射免疫扩散法测定尿肌红蛋白是一个诊断急性心肌梗塞的有价值方法。方法:从60例临床和心电图诊断为急性心肌梗
Myoglobin is a normal component of skeletal muscle. Myoglobin can appear in serum or urine when the muscle is injured. Due to its small size (17,000 molecular weight) and its lack of binding to other serum proteins, myoglobin quickly filters from the kidneys and excretes through the urine. Therefore, urinary myoglobin can occur very early, and with the size of the muscle necrosis continued for some time. Myoglobin and skeletal myoglobin are immunologically identical. Many authors have measured myoglobin in urine and serum using immunoassay in patients with impaired myocardium, particularly in patients with myocardial infarction. This article observes the relationship between myoglobinuria and acute myocardial infarction, and points out that radioimmunoassay is a valuable method for the diagnosis of acute myocardial infarction. Methods: From 60 cases of clinical and electrocardiographic diagnosis of acute myocardial infarction