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近年来,胆管癌的发生率有逐年上升的趋势,约占肝胆系统恶性肿瘤的15%[1]。由于胆管癌的解剖位置特殊、早期诊断手段的限制及易向周围组织、血管和神经浸润转移等特点,外科根治性切除难度大,且容易早期发生浸润与转移,预后较差,这也与目前对胆管癌发病机制的无深入了解及缺乏早期诊断胆管癌的手段有关[2]。Ezrin蛋白是细胞骨架的
In recent years, the incidence of cholangiocarcinoma has increased year by year, accounting for about 15% of hepatobiliary malignancies [1]. Due to the special anatomical location of the cholangiocarcinoma, the limitations of early diagnosis and easy to the surrounding tissue, blood vessels and nerve infiltration and metastasis, surgical radical resection difficult, and prone to early invasion and metastasis, the prognosis is poor, which is also the current There is no in-depth understanding of the pathogenesis of cholangiocarcinoma and the lack of early diagnosis of cholangiocarcinoma [2]. Ezrin protein is cytoskeletal