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目的:探讨低剂量化疗对弱体能状态晚期消化道恶性肿瘤患者的临床治疗效果，并评价影响预后的因素。方法:回顾性分析2018年3月至2019年5月复旦大学附属中山医院厦门医院收治的118例弱体能状态晚期消化道恶性肿瘤患者的临床资料。采用Kaplan-Meier法对各因素分层患者进行生存分析，并行log-rank检验；采用Cox回归模型进行预后多因素分析，评价各临床病理因素与预后的关系。结果:118例患者中，食管癌16例（13.6%），胃癌41例（34.7%），结直肠癌48例（40.7%），胰腺癌13例（11.0%）。全组6个月、1年的总生存（OS）率分别为44.1%、10.2%。生存分析显示，血红蛋白≥ 100 g/L、血清清蛋白>40 g/L及胃肠道功能正常者OS较好（均n P<0.05），体能状态评分3分及伴疼痛患者OS较差（均n P 40 g/L and normal gastrointestinal function had better OS (all n P < 0.05), while patients with physical status score of 3 scores and pain had worse OS (all n P < 0.05). Cox multivariate analysis showed that after adjusting age and gender, hemoglobin level ( n HR = 0.314, 95% n CI 0.241-0.977, n P = 0.001), pain (n HR = 2.016, 95% n CI 1.697-7.038, n P = 0.008) and gastrointestinal function (n HR = 1.751, 95% n CI 1.607-6.080, n P = 0.036) were independent influencing factors of OS in advanced gastrointestinal cancer patients with weak physical condition after receiving low-dose chemotherapy.n Conclusions:Low-dose chemotherapy can still benefit advanced gastrointestinal cancer patients with weak physical condition. Hemoglobin level, pain and gastrointestinal function are independent prognostic factors for these patients.