1964年我所生化研究室在研究日本血吸虫的代谢时,曾观察到某些药物对日本血吸虫的柠檬酸代谢有一定的抑制作用。因而用了有“致死合成”作用的氟乙酸钠,以抑制日本血吸虫的柠檬酸代谢。进行小鼠实验治疗的结果,发现氟乙酸钠有显著的杀虫作用,但毒性也甚大。据报道氟乙酰胺对哺乳动物的毒性 In 1964 my biochemical laboratory in the study of Schistosoma japonicum metabolism, we have observed some of the drugs on the Japanese schistosome citric acid metabolism has some inhibition. Therefore, with the “lethal synthesis ” effect of sodium fluoride acetate to inhibit Schistosoma japonicum citric acid metabolism. Experimental results in mice, found that sodium fluoride has a significant insecticidal effect, but the toxicity is also great. Fluoroacetamide is reported to be toxic to mammals