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人的慢性放射性皮肤溃疡常发生在放疗后几十年,所以实验研究是比较困难的;尤其动物实验,难度较大。本文对2例人的慢性放射性皮肤溃疡和4例动物慢性放射性皮肤溃疡,进行了电镜观察。 [病例] 张某,男,58岁。因患肺癌左侧背部进行了钴-60照射,总剂量105Gy,引起慢性放射性皮肤溃疡,6个月未愈。李某,女,64岁,因乳腺癌转移术后放射治疗,总剂量60Gy,引起慢性放射性皮肤溃疡长达19年之久。均经复方B_(12)油治疗30天、60天后,取溃疡边缘肉芽组织,做电镜观察。
Chronic radiation of human skin ulcers often occur in the decades after radiotherapy, so experimental research is more difficult; in particular, animal experiments, more difficult. In this paper, 2 cases of chronic radiation-induced skin ulcers and 4 cases of chronic radiation-induced skin ulcers were observed by electron microscopy. [Case] Zhang, male, 58 years old. Due to lung cancer on the left back of cobalt -60 irradiation, the total dose of 105Gy, causing chronic radiation skin ulcers, 6 months healed. Lee, female, 64 years old, after radiation therapy for breast cancer metastases, the total dose of 60Gy, causing chronic radiation skin ulcers for up to 19 years. All of them were treated with compound B_ (12) oil for 30 days. After 60 days, the marginal granulation tissue of ulcer was taken and observed under electron microscope.