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Ⅱ型糖尿病以氧化应激增加和内皮功能紊乱为特征。二者在动脉粥样硬化性疾病发生和发展中起重要作用。短期动脉注射维生素C能增加Ⅱ型糖尿病患者内皮依赖的血管舒张反应,提示内皮功能障碍继发于氧化应激增加,可能原因为活性氧族如过氧化物阴离子阻断内皮来源的NO。为了解口服抗氧化剂能否降低Ⅱ型糖尿病患者氧化应激及改善内皮功能,我们研究一种新的类维生素E的水溶性抗氧化剂raxofelast在糖尿病及正常人中的作用。检测血浆8-epi-PGF2α浓度表示氧化应激,输注乙酰胆碱后血管的反应性表示内皮功能。
Type II diabetes is characterized by increased oxidative stress and endothelial dysfunction. Both play an important role in the development and progression of atherosclerotic disease. Short-term arterial injection of vitamin C can increase endothelium-dependent vasodilatation in patients with type 2 diabetes, suggesting that endothelial dysfunction secondary to increased oxidative stress may be due to reactive oxygen species such as peroxide anion blocking endothelium-derived NO. To understand whether oral antioxidants can reduce oxidative stress and improve endothelial function in type 2 diabetic patients, we investigated the role of a novel vitamin E-based water-soluble antioxidant, raxofelast, in both diabetic and normal subjects. Plasma concentrations of 8-epi-PGF2α were measured to indicate oxidative stress, and vascular responsiveness after infusion of acetylcholine indicated endothelial function.