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创制消炎痛的美国Merck公司的Shen等将消炎痛的类似物以电子计算机就构效关系进行了广泛的研究,发现茚类化合物抗炎效果较好,且胃肠道障碍和中枢神经作用较少。其中最安全有效的是Sulindac(中译名为双氟苯水杨酸)。 1.药物动力学:Sulindac从胃肠道吸收后,在肝中还原生成活性型硫化物,或经氧化生成无活性的砜,前者为可逆反应,在体内易氧化为Sulindac。Sulindac本身几无药
Indoline and other manufacturers of indomethacin Merck’s Shen similar indomethacin electronic computer-based structure-activity relationship has been extensively studied and found that indene compounds anti-inflammatory effect is better, and less gastrointestinal disorders and central nervous system . One of the safest and most effective is Sulindac (Chinese translation was called diflunisal). 1. Pharmacokinetics: After Sulindac is absorbed from the gastrointestinal tract, it is reduced to form active sulfide in the liver, or oxidized to form inactive sulfones. The former is reversible and is easily oxidized to Sulindac in the body. Sulindac itself almost no medicine