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目的分析结核分枝杆菌临床分离株对5种抗结核药物的药物敏感性。方法用改良罗氏培养法测定结核分枝杆菌临床分离株的耐药性(MIC)、耐药率。结果80株结核分枝杆菌临床分离株对INH、RFP、EMB、SM和LVFX的平均MIC分别为9.7μg/mL、30.1μg/mL、16.4μg/mL、38.7μg/mL和0.9μg/mL;耐药率分别是67.2%、35.0%、53.8%、63.8%和16.3%。总耐药率为83.75%;耐单药率为17.5%;耐多药率为66.3%;耐多药株占总耐药株的79.1%。结论80株结核分枝杆菌临床分离株耐药率和耐多药率都较高,结核病的防治将面临更大的困难。
Objective To analyze the drug sensitivity of five clinical isolates of Mycobacterium tuberculosis to five anti-TB drugs. Methods The drug resistance (MIC) and drug resistance of Mycobacterium tuberculosis clinical isolates were determined by modified Roche culture. Results The average MIC of clinical isolates from 80 strains of Mycobacterium tuberculosis to INH, RFP, EMB, SM and LVFX were 9.7μg / mL, 30.1μg / mL, 16.4μg / mL, 38.7μg / mL and 0.9μg / mL respectively; The resistance rates were 67.2%, 35.0%, 53.8%, 63.8% and 16.3% respectively. The total drug resistance rate was 83.75%; the single drug resistance rate was 17.5%; the multidrug resistance rate was 66.3%; the multidrug resistant strains accounted for 79.1% of the total drug resistant strains. Conclusion The clinical isolates of 80 strains of Mycobacterium tuberculosis have high rates of resistance and multidrug resistance, and prevention and treatment of tuberculosis will face greater difficulties.