Recently,a series of piperidine linked aminopyrimidine derivatives are reported as H1V-1 NNRTIs with good potency in both enzyme and antiviral assays1-3In c
Ligustrazine(tetramethyl pyrazine,TMP,a major effective component of Chinese traditional herbal medicine Chuanxiong,has been reported to be a multifunctiona
A novel series of β-amino pyrrole-2-carbonitrile derivatives was designed and synthesized based on the three-dimensional binding modes of Denagliptin1 and
Aminoglycosides are frequently prescribed broad spectrum antibiotics,which have been used for 70 years.However,the emergence of bacterial resistance is a th