目的　了解三氧化二砷 (As2 O3 )注射液对人肝功的影响及其转归 ,为合理、安全应用As2 O3 提供依据。方法　观察As2 O3 治疗前后、肝炎组与非肝炎组、饮酒组与非饮酒组、男性与女性肝功变化。结果　As2 O3 注射液对肝功损伤率为16 16 % ,轻度、中度和重度损伤分别为 75 0 %、18 75 %和 6 2 5 %。轻度和中度损伤者停砷剂、保肝治疗全部恢复 ,3例重度损伤者均有乙肝史 ,均死于肝功衰竭。结论　治疗剂量As2 O3 注射液对肝功的损伤较少见 ,且多为轻度、可逆的 ,但极少数为重度损伤 ,均死于肝功衰竭。其肝功损伤不仅与As2 O3 累积量呈正相关 ,也与饮酒、肝炎和男性等敏感因素有关 ,观察与处置应个体化 Objective To understand the effect of As2O3 on human liver function and its outcome in order to provide a basis for rational and safe application of As2 O3. Methods The changes of liver function were observed before and after As 2 O 3 treatment in Hepatitis group and non-Hepatitis group, drinking group and non-drinking group, male and female. Results As2 O3 injection had a 16 16% injury to the liver and 75 0%, 18 75% and 62 5% respectively for mild, moderate and severe injuries. Both mild and moderate injury stopped arsenic, liver protection all recovered, three cases of severe injury have history of hepatitis B, all died of liver failure. Conclusion The therapeutic dose of As 2 O 3 injection on liver function damage is rare, and more mild, reversible, but a very small number of severe injuries, all died of liver failure. The liver damage was not only positively correlated with the accumulation of As2 O3, but also with sensitive factors such as alcohol, hepatitis and males, and the observation and treatment should be individualized