怀孕小白鼠授予苯二氮杂类后,可诱发子代产生腭裂、露脑或颅脊柱裂畸形和肢体异常等。这可能与增加内源性肾上腺皮质激素浓度或加强GABA作用有关。母亲怀孕3mo内服地西泮,可使婴儿发生口/腭裂或腹股沟疝,亦可引起染色体畸变。孕初6wk服氯氮(艹卓)的畸胎发生率为11.4％,而服其它药物者仅4.6％。认为孕期(尤早期)不宜持续使用苯二氮杂(艹卓)类(BDZ)。若需使用,应小剂量、间歇给药。 Pregnant mice granted benzodiazepines, can induce offspring to produce cleft palates, deformity or cranial spina bifida malformations and limb abnormalities. This may be related to increased endogenous adrenocorticotropic hormone concentration or to enhance the role of GABA. Mother 3mo oral diazepam, can make the baby mouth / cleft palate or groin hernia, can also cause chromosomal aberrations. The incidence of teratogenesis at 6 weeks of early pregnancy was 11.4% for clozapine and 4.6% for other medications. It is not advisable to continue using benzodiazepines (BDZ) during pregnancy (especially early). For use, should be small doses, intermittent administration.