溃疡性结肠炎合井皮肤坏死性脓皮病(Pyoder-ma gangrenosum)较为少见,严重病例更少.我科于1996年3月收治1例,经治疗后取得满意效果、现报告如下:患者,男,54岁,住院号:558243.因反复脓血便5年并右小腿溃疡进行性增大2月入院,无发热、疼痛.行走困难、间歇跛行等情况.入院前5年反复出现脓血便.结肠镜检发现直肠至横结肠肠腔变形,肠粘膜弥漫性充血、水肿,粘膜面高低不平,触及易出血,表面见糜烂和小溃疡.并有粘液和渗出物,诊断为溃疡性结肠炎.以柳氮磺胺嘧啶治疗,,因出现严重过敏反应而中止,而以中药治疗,未服用过激素.查体:神清,消瘦,贫血貌.心肺无异常.腹平软,未触及腹部包块,左下腹深压痛;无反跳痛,肝脾肋缘下未触及,双肾区无叩痛,NS(-).双下肢凹陷性水肿.右小腿前、内、外侧见一27×17cm溃疡,内见较多脓性分泌物,有痂皮附着,并可见少量新鲜 Pyoder-ma gangrenosum is rare, with fewer serious cases.Our department received 1 case in March 1996 and achieved satisfactory results after treatment, the report is as follows: Patients, Male, 54 years old, hospital number: 558243. Due to repeated 5 years of sepsis and right leg ulcer increased sexual admissions in February, no fever, pain, walking difficulties, intermittent claudication, etc .. 5 years before admission, repeated pus and blood. Colonoscopy found that the rectum to transverse colon intestine deformation, diffuse congestion of the intestinal mucosa, edema, mucosal surface rugged, easy bleeding, surface erosion and small ulcers. And mucus and exudate, the diagnosis of ulcerative colitis. To sulfasalazine treatment, due to severe allergic reactions and termination, and Chinese medicine treatment, not taking hormones .Check the body: Shen Qing, weight loss, anemia appearance .Analyzing the heart and lungs .Abdominal flat, did not touch the abdominal mass , Left lower quadrant deep tenderness; no rebound tenderness, liver and spleen rib margin not touched, no percussion pain in the kidney area, NS (-) .Depression of both lower extremity edema .Front leg, medial and lateral see a 27 × 17cm ulcer See more purulent secretions, there are scabs attached, and see a small amount of fresh