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目的 :研究维生素 B1 2 滴鼻剂中维生素 B1 2 原料及附加剂—— 4种鼻粘膜吸收促进剂、4种高分子材料、2种防腐剂及 2种等渗剂对鼻粘膜纤毛运动的影响。方法 :在体蟾蜍上腭模型法。结果 :维生素 B1 2 原料、 1%PVP溶液、1% HPMC溶液、0 .8% MC溶液、0 .0 5 % CP溶液、0 .0 1%新洁尔灭溶液、0 .0 5 % EDTA溶液、2 .5 6%甘油溶液、5 .3 %甘露醇溶液、2 %β-环糊精混悬液对纤毛运动均无明显影响 ;1.8%氮酮混悬液、5 %吐温 -80溶液、枸橼酸盐缓冲液对纤毛运动有一定影响。结论 :维生素 B1 2 与适宜附加剂组合制成鼻腔给药制剂是可行的
OBJECTIVE: To study the effects of vitamin B1 2 raw materials and adjuvants on vitamin B1 2 nasal drops - four kinds of nasal absorption enhancers, four macromolecular materials, two preservatives and two kinds of isotonic agents on the movement of nasal mucociliary . Methods: Toad palate model method. Results: Vitamin B1 material, 1% PVP solution, 1% HPMC solution, 0.8% MC solution, 0.5% CP solution, 0.01% benzalkonium bromide solution, 0.05% EDTA solution, 5 6% glycerol solution, 5.3% mannitol solution, 2% β-cyclodextrin suspension had no significant effect on ciliary movement; 1.8% Azone solution, 5% Tween-80 solution, Acid buffer has some influence on ciliary movement. Conclusion: The combination of vitamin B1 2 and appropriate adjuvant is feasible for nasal administration