目的:建立顶空毛细管气相色谱法测定比阿培南中4种有机溶剂(甲醇、乙醇、丙酮、乙腈)残留量。方法:色谱柱为DM-624(6%氰丙基苯基-94%二甲基聚硅氧烷)毛细管柱,FID检测器,溶剂为水。结果:甲醇、乙醇、丙酮、乙腈线性关系良好,4种有机溶剂的平均回收率分别为96.4%,101.2%,95.8%,96.3%,RSD分别为2.1%,3.5%,2.2%,3.1%,样品测定结果满意。结论:方法灵敏、快速、准确,适用于测定比阿培南中的有机溶剂残留。 Objective: To establish a capillary gas chromatographic method for the determination of four kinds of organic solvents (methanol, ethanol, acetone, acetonitrile) in biapenem. Methods: The column was DM-624 (6% cyanopropylphenyl-94% dimethylpolysiloxane) capillary column with FID detector. The solvent was water. Results: The linear relationship between methanol, ethanol, acetone and acetonitrile was good. The average recoveries of four organic solvents were 96.4%, 101.2%, 95.8% and 96.3%, respectively. The RSDs were 2.1%, 3.5%, 2.2% and 3.1% Satisfactory results of sample determination. Conclusion: The method is sensitive, rapid and accurate and is suitable for the determination of organic solvent residues in biapenem.