随着对紫杉醇(taxol)作用机理的深入研究,作用于微管的药物已引起广泛的重视.微管是真核细胞的重要组成部分,参与许多细胞功能,包括染色体运动,细胞形状的变化,细胞内运动,稳定细胞膜表面受体及与纤毛、鞭毛有关的细胞运动.由于微管在细胞分裂中有着重要作用,一些干扰微管功能的化合物可使细胞停留在有丝分裂期,从而达到抗肿瘤的效果.因此,微管成为许多抗肿瘤药物的重要靶点,筛选抗微管药在抗癌药物研究中尤为令人注目. With the in-depth study on the mechanism of action of taxol, drugs that act on microtubules have attracted a great deal of attention.Microtubules are an important part of eukaryotic cells and involved in many cell functions, including chromosome movement, cell shape changes, Cell motility and stabilize cell membrane surface receptors and cell movement related to cilia and flagella.Because microtubules play an important role in cell division, some compounds that interfere with microtubule functions can make cells stay in mitosis, so as to achieve anti-tumor Therefore, microtubules become an important target for many antitumor drugs, screening anti-microtubule drugs in cancer research is particularly striking.