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目的观察拉西地平联合氯沙坦对2型糖尿病并发高血压患者早期肾功能损害的疗效。方法将有微量白蛋白尿的2型糖尿病并发高血压患者61例,随机分为3组,分别给予拉西地平4~8 mg;氯沙坦50~100 mg;拉西地平4~6 mg、氯沙坦50~100 mg。用药均1次/d,口服,疗程均为4个月,观察治疗前后血压和肾功能的变化。结果治疗4周后,各组患者血压比治疗前均有明显下降(P<0.01),联合治疗组比另外两组血压下降更明显(P<0.05)。治疗4个月后,各组尿微量白蛋白比治疗前均有明显下降(P<0.01),而联合治疗组比另外两组下降更为明显(P<0.05)。结论拉西地平、氯沙坦均有较好的降压降尿微量白蛋白作用,两药联用,效果更佳。
Objective To observe the effect of lacidipine and losartan on the early renal dysfunction in type 2 diabetic patients with hypertension. Methods Sixty-one patients with type 2 diabetes with microalbuminuria complicated with hypertension were randomly divided into 3 groups, which were given lacidipine 4 ~ 8 mg, losartan 50 ~ 100 mg, lacidipine 4 ~ 6 mg, Losartan 50 ~ 100 mg. Medication was 1 / d, oral, treatment were 4 months, before and after treatment to observe the changes in blood pressure and renal function. Results After 4 weeks of treatment, the blood pressure in each group was significantly lower than that before treatment (P <0.01). The blood pressure in combination therapy group was more obvious than that in the other two groups (P <0.05). After 4 months of treatment, urinary albumin in each group was significantly lower than that before treatment (P <0.01), but the combined treatment group was more obvious than the other two groups (P <0.05). Conclusion Both lacidipine and losartan have good antihypertensive and microalbuminuria effects, and the combination of the two drugs has better effect.