论文部分内容阅读
目的：分析大肠癌中血型抗原的表达及其与预后的关系。方法：应用免疫组化染色检测８６例远位大肠癌中Ａ、Ｂ、Ｈ、Ｌｅａ和Ｌｅｂ５种血型抗原，并进行随访观察。结果：５种血型抗原在大肠癌中呈不同程度的表达，高、中分化腺癌中Ａ、Ｂ、Ｈ抗原丢失时，其预后较差，低分化腺癌和粘液腺癌Ａ、Ｂ、Ｈ抗原不相配合表达时，预后差。Ｌｅａ和Ｌｅｂ抗原在各型大肠癌表达差异不明显。５种血型抗原表达与大肠癌Ｄｕｃｋ＇ｓ分期关系不大。结论：Ａ、Ｂ、Ｈ抗原检测可能有助于判断大肠癌的预后。
Objective: To analyze the expression of blood group antigen in colorectal cancer and its relationship with prognosis. Methods: Immunohistochemical staining was used to detect five blood group antigens of A, B, H, Lea and Leb in 86 patients with distant colorectal cancer. Results: The five blood group antigens expressed differently in colorectal cancer. When the A, B, and H antigens were lost in high- and middle-differentiated adenocarcinomas, their prognosis was poor. Low-differentiation adenocarcinoma and mucinous adenocarcinoma A, B, and H When the antigen is not co-expressed, the prognosis is poor. There was no significant difference in the expression of Lea and Leb antigens in various colorectal cancers. The expression of five blood group antigens had little relationship with the Duck’s stage of colorectal cancer. Conclusion: Detection of A, B, H antigens may be helpful in judging the prognosis of colorectal cancer.