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目的探讨化疗-放疗-化疗序贯治疗局部晚期胃癌的临床疗效。方法选取2012年1月—2014年1月侯马市人民医院收治的局部晚期胃癌患者76例,按随机数字表法分为观察组与对照组,各38例。对照组患者予以单纯化疗治疗,观察组患者予以化疗-放疗-化疗序贯治疗。观察两组患者临床疗效、临床症状(腹痛、恶心呕吐、便血、进食梗阻)缓解情况、生活质量、毒副作用发生情况及1年生存情况。结果观察组患者总有效率高于对照组,腹痛、恶心呕吐、进食梗阻、便血缓解率高于对照组,生活质量优于对照组,1年生存率高于对照组,差异有统计学意义(P<0.05)。结论化疗-放疗-化疗序贯治疗局部晚期胃癌的临床疗效显著,可改善患者的临床症状,提高患者的生活质量及1年生存率,且毒副作用少。
Objective To investigate the clinical effects of chemotherapy-radiotherapy-chemotherapy sequential treatment of locally advanced gastric cancer. Methods From January 2012 to January 2014, 76 patients with locally advanced gastric cancer admitted to Houma People’s Hospital were divided into observation group and control group according to the random number table method, 38 cases in each group. Patients in the control group were treated with chemotherapy alone, while patients in the observation group were treated with chemotherapy-radiotherapy-chemotherapy sequential therapy. The clinical efficacy, clinical symptoms (abdominal pain, nausea and vomiting, blood in the stool, eating obstruction), the quality of life, the side effects and the one-year survival were observed in two groups. Results The total effective rate of the observation group was higher than that of the control group. The abdominal pain, nausea and vomiting, eating obstruction, and the reduction of blood in the stool were higher than those in the control group, and the quality of life was better than the control group. The 1-year survival rate was significantly higher than that of the control group P <0.05). Conclusions Chemotherapy - radiotherapy - chemotherapy sequential treatment of locally advanced gastric cancer clinical significant effect, can improve the patient ’s clinical symptoms, improve patient quality of life and 1 year survival rate, and less toxic side effects.