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本文探讨长效醋酸甲孕酮避孕针（ＤＭＰＡ）对中国妇女骨质代谢的影响。自愿使用１５０ｍｇ ＤＭＰＡ避孕者３０人为实验组；采用阴茎套避孕者３０人组成对照组。１ａ后测定两组血清雌二醇（Ｅ２）、血清碱性磷酸酶（ＡＫＰ）、尿钙／肌酐（Ｃａ／Ｃｒ）、尿羟脯氨酸／肌酐（Ｈｙｐ／Ｃｒ）及非惯用臂桡尺骨超远端骨矿含量（ＢＭＣ）、骨矿密度（ＢＭＤ）。结果显示：两组血清雌二醇、血清碱性磷酸酶、尿钙／肌酐、尿羟脯氨酸／肌酐差异无显著性（Ｐ＞０．０５），两组臂桡尺骨超远端骨矿含量、骨矿密度无显著性差异（Ｐ＞０．０５）。这说明使用 ＤＭＰＡ １ａ对中国妇女骨质代谢无影响。
This article discusses the effect of long-acting medroxyprogesterone acetate (DMPA) on bone metabolism in Chinese women. 30 volunteers who used 150 mg DMPA contraceptives voluntarily as the experimental group; 30 people who used condoms as the control group. Serum estradiol (E2), serum alkaline phosphatase (AKP), urinary calcium / creatinine (Ca / Cr), urinary hydroxyproline / creatinine (Hyp / Cr) Super distal bone mineral content (BMC), bone mineral density (BMD). The results showed that serum estradiol, serum alkaline phosphatase, urinary calcium / creatinine, urinary hydroxyproline / creatinine were not significantly different between the two groups (P> 0.05) Content, bone mineral density no significant difference (P> 0.05). This shows that the use of DMPA 1a has no effect on Chinese women’s bone metabolism.