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目的 通过测定胰头和壶腹部癌肿瘤和癌周组织微血管密度 ,分析其与常规临床病理参数的关系及在预后中的意义。方法 在对 6 7例胰头和壶腹部癌患者回顾性调查的基础上 ,采用免疫组织化学和常规病理学方法 ,并借助自动图像分析技术 ,半定量测定肿瘤和癌周组织微血管密度。结果 ①高分化癌微血管计数明显低于低分化癌 (P <0 0 1) ;肿瘤直径 <3cm者微血管计数明显低于直径≥ 3cm者 (P <0 0 5 ) ;②有区域淋巴结内癌转移者微血管计数明显高于无区域淋巴结内癌转移者 (P <0 0 1) ;③非整倍体肿瘤的微血管计数明显高于整倍体肿瘤 (P <0 0 5 ) ;④随着肿瘤微血管密度的增加 ,术后生存率呈下降趋势 ,而复发和转移率却呈上升趋势。结论①胰头和壶腹部癌微血管密度是其他临床病理参数的有益补充 ;②微血管密度与预后关系密切 ,可望成为一个重要的预后参数
OBJECTIVE: To determine the relationship between the microvessel density and the clinicopathologic parameters in pancreatic and ampullary carcinoma and peri-cancerous tissues and its significance in prognosis. Methods Based on a retrospective survey of 67 patients with pancreatic head and ampullary carcinoma, immunohistochemical and routine pathological methods were used to semi-quantitatively determine the microvessel density of tumor and pericancerous tissue by means of automatic image analysis. Results ① The microvessel count of well-differentiated carcinoma was significantly lower than that of poorly differentiated carcinoma (P <0.01). The microvessel count of tumor with diameter <3cm was significantly lower than that of tumor with diameter> 3cm (P <0.05) (P <0.01); (3) The microvessel count of aneuploidy was significantly higher than that of euploid (P <0.05); ④As the microvessel count of tumor was higher than that of euploid The increase of density, postoperative survival rate showed a downward trend, while the recurrence and metastasis rate was on the rise. Conclusions ① The microvessel density of pancreatic head and ampullary carcinoma is a useful supplement for other clinical and pathological parameters. ② The microvessel density is closely related to the prognosis, which is expected to become an important prognostic parameter